One of the main constraints of cryopreservation is the difficulty in rewarming complex systems out of vitrification without inducing significant damage. This two part project will test and advance rewarming techniques based on breakthrough work from Dr. Ramón Risco. The project would use an arrangement of real time MRI guided ultrasound transfusers to uniformly warm a larger sample while achieving high warming rates. The first part of the project would fund a proof of principle to rewarm a smaller organ. If successful the second part of the project would scale up this technology (by increasing the arrangement of ultrasound transfusers) to allow for rewarming of larger samples potentially including human organs.
Project Presentation by Dr. Ramón Risco